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However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions.
This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Conclusion: Sodium nitrite administered iv immediately prior to reperfusion in patients with acute STEMI did not reduce infarct size. This contributes up to 50% of the final infarct size. In pre-clinical models nitrite potently protects against IRI in the heart and other organs. A potential benefit in diabetics warrants further study. Funding, Ethics, Regulatory Approvals and Registration: This study was funded by the UK Medical Research Council.